• Pediatric blood & cancer · Oct 2013

    Multicenter Study Meta Analysis Clinical Trial

    Association between baseline fetal hemoglobin levels and incidence of severe vaso-occlusive pain episodes in children with sickle cell anemia.

    • Pallav Bhatnagar, Jeffrey R Keefer, James F Casella, Emily A Barron-Casella, Christopher J Bean, Craig W Hooper, Amanda B Payne, Dan E Arking, and Michael R Debaun.
    • McKusick-Nathans Institute of Genetic Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
    • Pediatr Blood Cancer. 2013 Oct 1; 60 (10): E125-7.

    AbstractThe ameliorating effect of high fetal hemoglobin (HbF) levels on the incidence of pain episodes in sickle cell anemia (SCA) is well-known; however, in children this relationship is less clearly established. We hypothesized that higher HbF levels in children with SCA are associated with fewer severe pain episodes. A meta-analysis of data from the Silent Infarct Transfusion Trial (n = 456) and the Cooperative Study of Sickle Cell Disease (n = 764), demonstrated that baseline HbF levels were associated with the incidence of severe pain, commonly defined across studies as an event requiring hospitalization (P-value = 0.02).Copyright © 2013 Wiley Periodicals, Inc.

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