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- Donald R Royall, Raymond F Palmer, and Texas Alzheimer's Research and Care Consortium.
- Department of Psychiatry, The University of Texas Health Science Center, San Antonio, TX, USA; Department of Medicine, The University of Texas Health Science Center, San Antonio, TX, USA; Department of Family and Community Medicine, The University of Texas Health Science Center, San Antonio, TX, USA; South Texas Veterans' Health System, Audie L. Murphy Division GRECC, San Antonio, TX, USA. Electronic address: royall@uthscsa.edu.
- Neurobiol. Aging. 2014 Feb 1; 35 (2): 336-44.
AbstractWe have used structural equation models to explicitly distinguish functional status, and therefore "dementia-relevant" variance in cognitive task performance (i.e., "δ") from that which is unrelated to a dementing process. Our approach results in a relatively "error-free" continuous variable that can serve as a dementia-specific phenotype. In this study, we associate δ with cytokines and other serum biomarkers in a well characterized Alzheimer's disease cohort, the Texas Alzheimer's Research and Care Consortium. Independent of covariates, δ is associated significantly with 12 serum biomarkers. These associations appear to be specific to non-Hispanic white participants. Copyright © 2014 Elsevier Inc. All rights reserved.
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