Neurobiology of aging
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We have used structural equation models to explicitly distinguish functional status, and therefore "dementia-relevant" variance in cognitive task performance (i.e., "δ") from that which is unrelated to a dementing process. Our approach results in a relatively "error-free" continuous variable that can serve as a dementia-specific phenotype. ⋯ Independent of covariates, δ is associated significantly with 12 serum biomarkers. These associations appear to be specific to non-Hispanic white participants.
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Neurobiology of aging · Feb 2014
Assessing the role of the TREM2 p.R47H variant as a risk factor for Alzheimer's disease and frontotemporal dementia.
A non-synonymous genetic rare variant, rs75932628-T (p. R47H), in the TREM2 gene has recently been reported to be a strong genetic risk factor for Alzheimer's disease (AD). Also, rare recessive mutations have been associated with frontotemporal dementia (FTD). ⋯ Finally, none of the FTD patients harbored this genetic variant. These data strongly support the important role of p. R47H in AD risk, and suggest that this rare genetic variant is not related to FTD.