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Review
Treating age-related macular degeneration - interaction of VEGF-antagonists with their target.
- A Klettner and J Roider.
- UK S-H, Department of Ophthalmology, Campus Kiel, Hegewischstr. 2, 24105 Kiel, Germany. aklettner@ophthalmol.uni-kiel.de
- Mini Rev Med Chem. 2009 Aug 1; 9 (9): 1127-35.
AbstractThe neutralization of VEGF is the current treatment of choice for age-related macular degeneration. Current approaches include anti-VEGF-antibodies and -Fab Fragments, aptamers, soluble receptors (Traps) and siRNA. The molecular properties of VEGF and its antagonists are reviewed and the pathways of action of these substances are discussed.
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