Mini reviews in medicinal chemistry

The most recent articles from: Mini Rev Med Chem August 2009

Mini Rev Med Chem · Aug 2009

Review

Treating age-related macular degeneration - interaction of VEGF-antagonists with their target.

The neutralization of VEGF is the current treatment of choice for age-related macular degeneration. Current approaches include anti-VEGF-antibodies and -Fab Fragments, aptamers, soluble receptors (Traps) and siRNA. The molecular properties of VEGF and its antagonists are reviewed and the pathways of action of these substances are discussed.

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