• J. Neuroimmunol. · Jul 2020

    Hemorrhagic encephalopathy associated with COVID-19.

    • Jonathan D Krett, Gordon A E Jewett, Charissa Elton-Lacasse, Kevin Fonseca, Christopher Hahn, Selena Au, and Marcus W Koch.
    • Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada. Electronic address: jonathan.krett1@ucalgary.ca.
    • J. Neuroimmunol. 2020 Jul 14; 346: 577326.

    AbstractThe mechanisms for neurological complications of COVID-19, the disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), are not yet well understood. We present a critically ill man with a COVID-19-associated hemorrhagic encephalopathy. SARS-CoV-2 RNA was not detected in cerebrospinal fluid (CSF) or blood. CSF analyses suggested dysregulation of pro-inflammatory cytokine pathways, particularly tumor necrosis factor-α and interleukin-6, consistent with a cytokine release syndrome. The patient gradually recovered with supportive care and neurological rehabilitation. Awareness of this clinical entity may facilitate the identification of patients with a potentially remediable cause of encephalopathy in COVID-19.Copyright © 2020 Elsevier B.V. All rights reserved.

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