Consensus on hemophilia in Mexico.

Gac Med Mex · Jan 2021

Consensus on hemophilia in Mexico.

Hemophilia is a hemorrhagic disorder with a sex-linked inherited pattern, characterized by an inability to amplify coagulation due to a deficiency in coagulation factor VIII (hemophilia A or classic) or factor IX (hemophilia B). Sequencing of the genes involved in hemophilia has provided a description and record of the main mutations, as well as a correlation with the various degrees of severity. ⋯ This document is a review and consensus of the main genetic aspects of hemophilia, from the inheritance pattern to the concept of women carriers, physiopathology and classification of the disorder, the basic and confirmation studies when hemophilia is suspected, the various treatment regimens based on infusion of the deficient coagulation factor as well as innovative factor-free therapies and recommendations for the management of complications associated with treatment (development of inhibitors and/or transfusion-transmitted infections), or secondary to articular hemorrhagic events (hemophilic arthropathy). Finally, relevant reviews of clinical and treatment aspects of hemorrhagic pathology characterized by acquired deficiency of FVIII secondary to neutralized antibodies named acquired hemophilia.

expand abstract… or not…
- José L López-Arroyo, Juan M Pérez-Zúñiga, Laura E Merino-Pasaye, Azucena Saavedra-González, Luisa María Alcivar-Cedeño, José Luis Álvarez-Vera, Irene Anaya-Cuellar, Luara L Arana-Luna, David Ávila-Castro, Ramón A Bates-Martín, Gabriela Cesarman-Maus, Lénica A Chávez-Aguilar, Peña-CelayaJosé A de laJAHematology department, Centro Médico Nacional 20 de Noviembre, ISSSTE, Mexico City. Mexico., María E Espitia-Ríos, Patricia Estrada-Domínguez, Denisse Fermín-Caminero, Willy Flores-Patricio, Jaime García Chávez, María T García-Lee, Ma Del Carmen González-Pérez, Ma Del Carmen González-Rubio, Ma Guadalupe González-Villareal, Fabiola Ramírez-Moreno, Ana K Hernández-Colin, Eleazar Hernández-Ruiz, Wilfrido Herrera-Olivares, Faustino Leyto-Cruz, Sergio Loera-Fragoso, Annel Martínez-Ríos, María R Miranda-Madrazo, Alba Morales-Hernández, Lorena Nava-Villegas, Juan J Orellana-Garibay, Orlando G Palma-Moreno, Eugenia P Paredes-Lozano, Paula Peña-Alcántara, Uendy Pérez-Lozano, Yayra M Pichardo-Cepín, Ana Carolina Reynoso-Pérez, Mishel Rodríguez-Serna, Flavio Rojas-Castillejos, Hilda Romero-Rodelo, Josué I Ruíz-Contreras, Adela Segura-García, Karina Silva-Vera, Paulina M Soto-Cisneros, Ana L Tapia-Enríquez, Martha G Tavera-Rodríguez, Óscar Teomitzi-Sánchez, Fredy Tepepa-Flores, María D Valencia-Rivas, Teresa Valle-Cárdenas, Ana Varela-Constantino, Adrián Javier-Morales, Mario A Martínez-Ramírez, Sergio Tena-Cano, Ricardo Terrazas-Marín, Shendel P Vilchis-González, Atenas Villela-Peña, Verónica Mena-Zepeda, and Martha Alvarado Ibarra.
- Hematology department, Hospital General "B" del ISSSTE, Ciudad Juárez, Chih. Mexico.
- Gac Med Mex. 2021 Jan 1; 157 (Suppl 1): S1-S35.
AbstractHemophilia is a hemorrhagic disorder with a sex-linked inherited pattern, characterized by an inability to amplify coagulation due to a deficiency in coagulation factor VIII (hemophilia A or classic) or factor IX (hemophilia B). Sequencing of the genes involved in hemophilia has provided a description and record of the main mutations, as well as a correlation with the various degrees of severity. Hemorrhagic manifestations are related to levels of circulating factor, mainly affecting the musculoskeletal system and specifically the large joints (knees, ankles, and elbows). This document is a review and consensus of the main genetic aspects of hemophilia, from the inheritance pattern to the concept of women carriers, physiopathology and classification of the disorder, the basic and confirmation studies when hemophilia is suspected, the various treatment regimens based on infusion of the deficient coagulation factor as well as innovative factor-free therapies and recommendations for the management of complications associated with treatment (development of inhibitors and/or transfusion-transmitted infections), or secondary to articular hemorrhagic events (hemophilic arthropathy). Finally, relevant reviews of clinical and treatment aspects of hemorrhagic pathology characterized by acquired deficiency of FVIII secondary to neutralized antibodies named acquired hemophilia.Copyright: © 2020 Permanyer.

Pubmed Free full text Copy Citation Plaintext

Add institutional full text...
Notes
Knowledge, pearl, summary or comment to share?

300 characters remaining

help

You can also include formatting, links, images and footnotes in your notes

Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.

Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.

Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.

Links can be included with: [my link to pubmed](http://pubmed.com)

Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")

For footnotes use [^1](This is a footnote.) inline.

Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..
hide…

Consensus on hemophilia in Mexico.

Notes

300 characters remaining

help

You can also include formatting, links, images and footnotes in your notes

What will the 'Medical Journal of You' look like?

Start your free 21 day trial now.