• Leandro Augusto Pinto Pereira, Francisco Carlos Groppo, Bergamaschi Cristiane de Cássia Cde C, John Gerard Meechan, Juliana Cama Ramacciato, Rogério Heládio Lopes Motta, and José Ranali.
• Department of Pharmacology, Anesthesiology, and Therapeutics, São Leopoldo Mandic Dental School, Campinas, Brazil. leandroapp@sedcare.com.br
• Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Aug 1; 116 (2): e85-91.

ObjectiveThe aim of this study was to compare the cardiovascular effects and the anesthetic efficacy of intraosseous injections of 4% articaine with 1:100,000 epinephrine (EPI100) or 4% articaine with 1:200,000 epinephrine (EPI200).Study DesignIn this prospective, randomized, double-blind study, 0.9 mL EPI100 and EPI200 solutions were administered for endodontic treatment of mandibular molars with symptomatic irreversible pulpitis in 60 patients. The anesthetic success and pain during anesthesia were evaluated by visual analog scale. The cardiovascular parameters evaluated were heart rate, diastolic/systolic blood pressure, pulse oximetry, and electrocardiogram changes.ResultsBoth solutions provided high anesthetic efficacy (96.8% and 93.1% for EPI100 and EPI200, respectively; P > .05), and the cardiovascular parameters showed minimal incidences of significant differences throughout the clinical procedure.ConclusionsThe epinephrine concentration did not affect the efficacy of 4% articaine, and both solutions produced a high success level of pulpal anesthesia. Intraosseous delivery by slow speed of injection did not induce significant clinical changes in cardiovascular parameters.Copyright © 2013 Elsevier Inc. All rights reserved.

41 keywords...

hide…