• Rachel Wurth, Michelle Hajdenberg, Francisco J Barrera, Skand Shekhar, Caroline E Copacino, Pablo J Moreno-Peña, Omar A M Gharib, Forbes Porter, Swapnil Hiremath, Janet E Hall, Ernesto L Schiffrin, Graeme Eisenhofer, Stefan R Bornstein, Juan P Brito, José Gerardo González-González, Constantine A Stratakis, René Rodríguez-Gutiérrez, and Fady Hannah-Shmouni.
• NICHD, National Institutes of Health, Bethesda, Maryland, USA.
• Postgrad Med J. 2022 May 1; 98 (1159): 372379372-379.

AimThe aim of this study was to systematically appraise the quality of a sample of COVID-19-related systematic reviews (SRs) and discuss internal validity threats affecting the COVID-19 body of evidence.DesignWe conducted a scoping review of the literature. SRs with or without meta-analysis (MA) that evaluated clinical data, outcomes or treatments for patients with COVID-19 were included.Main Outcome MeasuresWe extracted quality characteristics guided by A Measurement Tool to Assess Systematic Reviews-2 to calculate a qualitative score. Complementary evaluation of the most prominent published limitations affecting the COVID-19 body of evidence was performed.ResultsA total of 63 SRs were included. The majority were judged as a critically low methodological quality. Most of the studies were not guided by a pre-established protocol (39, 62%). More than half (39, 62%) failed to address risk of bias when interpreting their results. A comprehensive literature search strategy was reported in most SRs (54, 86%). Appropriate use of statistical methods was evident in nearly all SRs with MAs (39, 95%). Only 16 (33%) studies recognised heterogeneity in the definition of severe COVID-19 as a limitation of the study, and 15 (24%) recognised repeated patient populations as a limitation.ConclusionThe methodological and reporting quality of current COVID-19 SR is far from optimal. In addition, most of the current SRs fail to address relevant threats to their internal validity, including repeated patients and heterogeneity in the definition of severe COVID-19. Adherence to proper study design and peer-review practices must remain to mitigate current limitations.© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.

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