• Zhen-Hua Gong, Jian-Feng Ji, Jun Yang, Tie Xiang, Chang-Kai Zhou, Xuan-Liang Pan, and Jian Yao.
• Department of Burn and Plastic Surgery, The First People's Hospital of Nantong, Nantong, Jiangsu Province, China.
• Kaohsiung J Med Sci. 2017 Jan 1; 33 (1): 24-29.

AbstractKeloid disease (KD) is a benign fibroproliferative scarring condition of unknown etiopathogenesis. Plasminogen activator inhibitor-1 (PAI-1) and vitamin D receptor (VDR) have been shown to play important roles in the progression of tissue fibrosis; therefore, both these genes are potential susceptibility genes for KD. We aimed to determine whether the gene expression levels of PAI-1 and VDR are altered in Chinese KD patients. We measured the expression of PAI and VDR in human peripheral blood lymphocytes in 236 patients with keloid and 219 age- and sex-matched healthy controls by quantitative real-time polymerase chain reaction. We found that PAI-1 expression in peripheral blood lymphocytes was significantly higher in patients with KD than in control individuals (p < 0.0001), while VDR expression was significantly lower in KD patients than in control individuals (p < 0.0001). High levels of PAI-1 and low levels of VDR expression were significantly associated with an increased risk for KD. PAI-1 and VDR might play important roles in keloid development. Gene expression levels of PAI-1 and VDR may, therefore, be used as potential markers for the prediction of keloid development after scarring.Copyright © 2016. Published by Elsevier Taiwan.

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