• Int. Arch. Allergy Immunol. · Jan 2020

    Review

    Strategies to Prevent SARS-CoV-2-Mediated Eosinophilic Disease in Association with COVID-19 Vaccination and Infection.

    • Hans-Uwe Simon, Alexander V Karaulov, and Martin F Bachmann.
    • Institute of Pharmacology, University of Bern, Bern, Switzerland, hus@pki.unibe.ch.
    • Int. Arch. Allergy Immunol. 2020 Jan 1; 181 (8): 624-628.

    AbstractA vaccine to protect against COVID-19 is urgently needed. Such a vaccine should efficiently induce high-affinity neutralizing antibodies which neutralize SARS-CoV-2, the cause of COVID-19. However, there is a concern regarding both vaccine-induced eosinophilic lung disease and eosinophil-associated Th2 immunopotentiation following infection after vaccination. Here, we review the anticipated characteristics of a COVID-19 vaccine to avoid vaccine-associated eosinophil immunopathology.© 2020 S. Karger AG, Basel.

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