• Cemal Orhan, Füsun Erten, Beşir Er, Mehmet Tuzcu, Nurhan Şahin, Öznur Ece Durmaz Kurşun, Vijaya Juturu, and Kazim Şahin.
• Department of Animal Nutrition, Faculty of Veterinary Medicine, Fırat University, Elazığ, Turkey
• Turk J Med Sci. 2021 Aug 30; 51 (4): 2167-2176.

Background/AimThis study was conducted to elucidate the effects of lutein/zeaxanthin isomers (L/Zi) on lipid metabolism, oxidative stress, NF-κB/Nrf2 pathways, and synaptic plasticity proteins in trained rats.Materials And MethodsWistar rats were distributed into four groups: 1) control, 2) L/Zi: rats received L/Zi at the dose of 100 mg/kg by oral gavage, 3) exercise, 4) exercise+L/Zi: rats exercised and received L/Zi (100 mg/kg) by oral gavage. The duration of the study was eight weeks.ResultsExercise combined with L/Zi reduced lipid peroxidation and improved antioxidant enzyme activities of muscle and cerebral cortex in rats (p < 0.001). In the Exercise + L/Zi group, muscle and cerebral cortex Nrf2 and HO-1 levels increased, while NF-κB levels decreased (p <0.001). Also, L/Zi improved BDNF, synapsin I, SYP, and GAP-43 levels of the cerebral cortex of trained rats (p < 0.001). The highest levels of BDNF, synapsin SYP, and GAP-43 in the cerebral cortex were determined in the Exercise+L/Zi group.ConclusionThese results suggested that exercise combined with L/Zi supplementation might be effective to reduce neurodegeneration via improving neurotrophic factors and synaptic proteins, and oxidative capacity in the cerebral cortex.This work is licensed under a Creative Commons Attribution 4.0 International License.

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