• Turk J Med Sci · Aug 2021

    Histopathological effects of Aloe vera on wound healing process in penile fracture model: An experimental study.

    • Kadir Turgay Akgül, Engin Doğantekin, Elif Özer, Mustafa Kotanoğlu, Yusuf Gökkurt, and Sema Hücümenoğlu.
    • Department of Urology, Ankara Training and Research Hospital, University of Health Sciences, Ankara, Turkey
    • Turk J Med Sci. 2021 Aug 30; 51 (4): 2193-2197.

    Background/AimThis study assessed the histopathological effects of aloe vera (AV) on penile fractures (PF) formed experimentally in rat model.Materials And MethodsThirty-two Wistar adult male rats (220 to 250 g) were used. The PF model was created experimentally with a number 15 lancet. After the interventions, all of the rats were randomly and equally divided into 4 groups. In the first group, incision was not closed (group C). In the second group, AV was locally applied onto incision without suturing for 3 days (group AV). In the third group, the incision line was closed primarily (group PR). In the last group, AV was applied to primary repair region for 3 days (group PAV). All groups were compared to each other according to presence of fibrosis, inflammation, and hyperemia-bleeding.ResultsHyperemia and bleeding were seen in all groups with varying degrees and the difference between groups was insignificant (p = 1.000). According to inflammation, there was a significant difference between all groups (p = 0.031). No significant inflammation was observed in group AV and therefore, group AV had a better score than group PR (p = 0.026). In group PAV, inflammation was less seen than group PR, however, the difference was insignificant (p = 0.119). According to fibrosis, group AV and group PAV had same fibrosis rates. Fibrosis was observed in 2 (25%) rats in each group. When group PR was compared with group AV and group PAV, there were no significant differences according to cavernosal tissue healing with fibrosis (p = 0.132 and p = 0.132, respectively).ConclusionLocal application of AV onto the PF region without closing with suture decreased inflammation in rats.This work is licensed under a Creative Commons Attribution 4.0 International License.

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