• Ayça Emsen, Hande Köksal, Hülya Uçaryılmaz, Naim Kadoglou, and Hasibe Artaç.
• Department of Pediatric Immunology and Allergy, Faculty of Medicine, Selçuk University, Konya, Turkey
• Turk J Med Sci. 2021 Aug 30; 51 (4): 1905-1911.

Background And AimThis study analyzed peripheral blood lymphocyte subsets to determine their role in the etiopathogenesis of IGM.Materials And MethodsThis study includes 51 pathologically proven IGM patients (active disease: 26 and in remission: 25) and 28 healthy volunteers. The analyses of lymphocyte subsets were performed by flow cytometric immunophenotyping.ResultsThe percentage of T helper lymphocyte of all IGM patients were lower than control groups (p = 0.001). Absolute cytotoxic T lymphocyte count (p = 0.03), both percentage (p = 0.035) and absolute count (p = 0.002) of the natural killer cells, and both percentage (p = 0.038) and absolute count (p = 0.008) of natural killer T cells, were higher than the control group. The T helper lymphocyte percentage of the patients with active disease was lower than the control group (p = 0.0003). The absolute cytotoxic T lymphocyte (p = 0.029) and natural killer T cells (p = 0.012) of the patients with active disease were higher than the control group.ConclusionIdiopathic granulomatous mastitis is defined as a localized form of granulomatous disorders. However, the observed changes in T cells, NK, and NKT cells suggest that there is systemic immune dysregulation in patients with IGM.This work is licensed under a Creative Commons Attribution 4.0 International License.

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