• Tuğba Yanık Yalçın, Özlem Azap, Adem Köse, Yaşar Bayındır, Elif Mükime Sarıcaoğlu, Güle Çınar, Yeşim Uygun Kızmaz, Ebru Kurşun, Hikmet Eda Alışkan, Yasemin Tezer Tekçe, Oya Özlem Eren Kutsoylu, Tufan Egeli, Alpay Arı, Yurdagül Albayrak, Hatice Çabadak, Seçil Deniz, Kübra Demir Önder, Filiz Kızılateş, Selçuk Özger, Özlem Güzel Tunçcan, and Mehmet Haberal.
• Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Başkent University, Ankara, Turkey
• Turk J Med Sci. 2021 Aug 30; 51 (4): 1960-1968.

Background/AimThe aim of this study is to evaluate the distribution, sources, clinical features, and mortality rates of bacteremia due to evaluation of extensively drug-resistant (XDR) gram negative among solid-organ transplant (SOT) recipients.Materials And MethodsA retrospective study of SOT recipients with bacteremia due to XDR gram-negative pathogens in 11 centers between 2016 and 2018 was conducted. Patients’ records were evaluated.ResultsOf 171 bacteremia that occurred in 164 SOT recipients, 93 (56.7%) were liver, 46 (28%) kidney, 14 (8.5%) heart, and 11 (6.7%) lung recipients. Bacteremia episodes were recorded in the first year in 63.7% of the patients (n = 109), early-onset bacteremia was recorded in 45% (n = 77) of the episodes. In multivariate analysis, catheter-associated bacteremia was an independent risk factor for 7-day mortality (p = 0.037), and early-onset bacteremia was found as an independent risk factor for 30-day mortality (p = 0.017).ConclusionDifficult-to-treat infections due to XDR bacteria in SOT recipients shadow the success of transplantation. Central venous catheters seem to be the main risk factor. Judicious use of medical devices is of pivotal importance.This work is licensed under a Creative Commons Attribution 4.0 International License.

26 keywords...

hide…