• British medical bulletin · Jun 2021

    Non-steroidal anti-inflammatory drugs and gabapentinoids for chronic lumbar pain: a Bayesian network meta-analysis of randomized controlled trials.

    • Filippo Migliorini, Nicola Maffulli, Jörg Eschweiler, Markus Tingart, and Alice Baroncini.
    • Department of Orthopaedics, University Clinic Aachen, RWTH Aachen University Clinic, Pauwelsstraße 30, 52074 Aachen, Germany.
    • Br. Med. Bull. 2021 Jun 10; 138 (1): 85-95.

    IntroductionSeveral pharmacological therapies have been proposed for the management of chronic low back pain (LBP), but no consensus has been reached yet.Source Of DataRecent published literatures identified accessing PubMed, Google scholar, Embase and Scopus.Areas Of AgreementExploring effective conservative alternatives to the surgical intervention is of especial interest.Areas Of ControversyThe efficacy and safety of non-steroidal anti-inflammatory drugs and gabapentinoids for chronic LBP are debated. Several clinical studies showed controversial results, and the most effective and safe class of drugs has not yet been clarified.Growing PointsThe effects of selective and non-selective NSAIDs and gabapentinoids in chronic LBP are probably over-estimated.Areas Timely For Developing ResearchThe effect of behavioural changes, including exercise, should be explored, alone or in combination with drugs.© The Author(s) 2021. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

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