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Ann Fr Anesth Reanim · May 2012
Case Reports[Extensive mesenteric ischemia related to naratriptan overuse associated with grapefruit juice absorption].
- S Gergaud, E Lermite, F Butel, C Soltner, and S Lasocki.
- Pôle d'anesthésie-réanimation, université d'Angers, CHU d'Angers, 4, rue Larrey, 49000 Angers, France.
- Ann Fr Anesth Reanim. 2012 May 1;31(5):472-4.
AbstractWe reported the case of a 61-year-old woman, who has been hospitalized in ICU because of an extensive mesenteric ischaemia, involving the small bowel, secondary to a naratriptan overuse. This mesenteric ischaemia was complicated by multiple organ failure and was responsible for extensive small bowel resection and left colectomy. A concomitant abundant absorption of grapefruit juice, a well-known P450 inhibitor, may have enhanced this naratriptan toxicity. This case underscore that an abdominal pain occurring in the context of headache treatment may be related to a mesenteric ischaemia.Copyright © 2012 Société française d’anesthésie et de réanimation (Sfar). Published by Elsevier SAS. All rights reserved.
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