• Simone F Kleiss, Kirsten F Ma, Mostafa El Moumni, Richte C L Schuurmann, Clark J Zeebregts, Marieke Haalboom, BokkersReinoud P HRPH0000-0001-6130-7311Department of Radiology, Medical Imaging Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., and de VriesJean-Paul P MJPMDepartment of Surgery, Division of Vascular Surgery, University Medical Center Groningen, University of Groningen, BA60, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands..
• Department of Surgery, Division of Vascular Surgery, University Medical Center Groningen, University of Groningen, BA60, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands. s.f.kleiss@umcg.nl.
• J Clin Monit Comput. 2022 Jun 1; 36 (3): 713-723.

PurposeHyperspectral imaging (HSI) is a noninvasive spectroscopy technique for determining superficial tissue oxygenation. The HyperView™ system is a hand-held camera that enables perfusion image acquisition. The evaluation of superficial tissue oxygenation is warranted in the evaluation of patients with peripheral arterial disease. The aim was to determine the reliability of repeated HSI measurements.MethodsIn this prospective cohort study, HSI was performed on 50 healthy volunteers with a mean age of 26.4 ± 2.5 years, at the lower extremity. Two independent observers performed HSI during two subsequent measurement sessions. Short term test-retest reliability and intra- and inter-observer reliability were determined, and generalizability and decision studies were performed. Transcutaneous oxygen pressure (TcPO2) measurements were also performed.ResultsThe short term test-retest reliability was good for the HSI values determined at the lower extremity, ranging from 0.72 to 0.90. Intra- and inter-observer reliability determined at different days were poor to moderate for both HSI (0.24 to 0.71 and 0.30 to 0.58, respectively) and TcPO2 (0.54 and 0.56, and 0.51 and 0.31, respectively). Reliability can be increased to >0.75 by averaging two measurements on different days.ConclusionThis study showed good short term test-retest reliability for HSI measurements, however low intra- and inter-observer reliability was observed for tissue oxygenation measurements with both HSI and TcPO2 performed at separate days in young healthy volunteers. Reliability of HSI can be improved when determined as a mean of two measurements taken on different days.© 2021. The Author(s).

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