• W A Kofke, N Shaheen, J McWhorter, E H Sinz, and G Hobbs.
• Department of Anesthesiology, West Virginia University Health Sciences Center, Morgantown, USA. Kofkea@uphs.upenn.edu
• J Clin Anesth. 2001 Aug 1; 13 (5): 335-8.

Study ObjectivesTo evaluate the cerebral vascular effects of cis-atracurium and rocuronium given after thiopental induction of anesthesia.DesignRandomized, single-blinded study.SettingUniversity-affiliated hospital.Patients39 adult ASA physical status I and II patients undergoing nonintracranial procedures.InterventionsPatients received intravenously (IV), either saline placebo, cis-atracurium, or rocuronium after induction of general anesthesia with thiopental sodium.MeasurementsThe right middle cerebral artery was insonated using a pulsed-wave range-gated transcranial Doppler, and data were recorded at preinduction, immediately postinduction, at injection of the study drug, and at 15-second intervals for 3 minutes thereafter. The variables recorded for each subject included the systolic, diastolic, and mean flow velocity, as well as pulsality index, systolic, diastolic, and mean arterial blood pressure (MAP), and end-tidal carbon dioxide concentration.Main ResultsNo significant differences between the groups were present in the postanesthetic induction maximal or minimal mean flow velocity.Conclusionscis-Atracurium and rocuronium, administered after thiopental, do not produce clinically relevant changes in cerebral blood flow velocity.

23 keywords...

hide…