• Tiago Eduardo Dias Gonçalves, Glaucia Santos Zimmermann, Luciene Cristina Figueiredo, Monique de Carvalho Souza, Daniele Ferreira da Cruz, Marta Ferreira Bastos, Hélio Doyle Pereira da Silva, and Poliana Mendes Duarte.
• Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, São Paulo, Brazil.
• J. Clin. Periodontol. 2015 May 1; 42 (5): 431-9.

AimThis study evaluated the effects of scaling and root planing (SRP) on gingival crevicular fluid (GCF) and serum levels of adipokines in patients with chronic periodontitis (CP) with or without obesity.MethodsTwenty patients with obesity and 20 patients without obesity, all with CP, received SRP. Serum and GCF levels of resistin, adiponectin, leptin, tumour necrosis factor [TNF]-α and interleukin [IL]-6 were evaluated by enzyme-linked immunosorbent assay at baseline, 3, 6 and 12 months post-therapy.ResultsSRP reduced the amounts of TNF-α in deep sites and increased the concentration of adiponectin in shallow sites of non-obese patients (p < 0.05). SRP increased the concentrations of TNF-α and leptin in patients with obesity (p < 0.05). GCF levels of TNF-α were higher in patients with obesity than in patients without obesity at all time-points (p < 0.05). There were no changes in serum levels of any adipokines for any group after therapy (p > 0.05). Patients with obesity exhibited higher serum levels of leptin at all time-points and IL-6 at 3 months post-therapy (p < 0.05).ConclusionsObesity may modulate systemic and periodontal levels of adipokines in favour of pro-inflammation, independently of periodontal therapy. SRP did not affect the circulating levels of adipokines in patients with or without obesity.© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

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