• Zuwwar Khan Jadoon, Sobia Shakeel, Abeera Saleem, Ali Khaqan, Sana Shuja, Qadeer Ul-Hasan, Shahzad A Malik, and Ali Riaz Raja R Department of Electrical Engineering, COMSATS Institute of Information Technology, Chak Shahzad Park Road, Islamabad, Pakistan..
• Department of Electrical Engineering, COMSATS Institute of Information Technology, Chak Shahzad Park Road, Islamabad, Pakistan.
• J Healthc Eng. 2017 Jan 1; 2017: 3153252.

GoalThe aim of this paper is to conduct a comprehensive comparative analysis between five different controllers for a drug infusion system in total intravenous anesthesia (TIVA) administration.MethodsThe proposed method models a dilution chamber with first order exponential decay characteristics to represent the pharmacokinetic decay of a drug. The dilution chamber is integrated with five different control techniques with a simulation-based comparative analysis performed between them. The design process is conducted using MATLAB SISOTOOL.ResultsThe findings show that each controller has its own merits and demerits. The results generated using MATLAB signify and confirm the effectiveness of PI and cascaded lead controllers, with cascaded lead controller as the best control technique to automate and control the propofol delivery.ConclusionIn this paper, different control techniques for measurement-based feedback-controlled propofol delivery is confirmed with promising results.SignificanceThe comparative analysis showed that this drug infusion platform, merged with the proper control technique, will perform eminently in the field of total intravenous anesthesia.

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