• Ann Fr Anesth Reanim · Jan 1990

    Comparative Study

    [Pharmacokinetics of drugs used during the period of cardiac support].

    • J Schüttler.
    • Institut für Anästhesiologie der Rheinischen Friedrich-Wilhelms-Universität Bonn, Venusberg.
    • Ann Fr Anesth Reanim. 1990 Jan 1; 9 (3): 208-11.

    AbstractDeep endobronchial instillation of epinephrine (2-5 mg in 5 ml saline, catheter of 50 cm in length), during cardiopulmonary resuscitation in man, results rapidly in efficient blood concentrations, similar to those obtained with i.v. route, but with the additional benefit of a more prolonged effect, due to a slower blood concentration decrease. Despite the large interindividual variations in resulting blood concentrations, also observed with the i.v. route, the endobronchial instillation of lidocaine (5-7 mg.kg-1 in 10 ml saline) results in most cases in blood concentrations located in the therapeutic range. As with epinephrine, the endobronchial route results in a prolonged, infusion-like effect. This can be of benefit for the prevention of recurrent ventricular fibrillation. This study provides further arguments for a more extensive use of the endobronchial route, especially in out-of-hospital resuscitation.

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