• A Zagon.
• University Department of Pharmacology, Oxford, UK.
• J. Auton. Nerv. Syst. 1995 May 17; 53 (1): 43-56.

AbstractPhysiological and pharmacological data suggest that the rostral ventromedial medulla (RVM) is an important site where integration between somatic and visceral functions might occur. The aim of the present study was to describe the interconnections between various nuclei of the rostral ventromedial medulla and thus reveal the possible anatomical basis for such functional interactions. The topography of anterogradely labelled internal projections was examined following iontophoretic microinjections of Phaseolus vulgaris leucoagglutinin (PHA-L). The results revealed that the nuclei of the rostral ventromedial medulla have strong interconnections and, to varying degrees, they also have bilateral projections into the rostral ventrolateral medulla. A particularly dense projection to widespread regions of the ventral medulla was traced from the raphe obscurus. Terminals, originating from the raphe pallidus were similarly dispersed but very low density in comparison. The focus of the projections of the gigantocellular nucleus pars ventralis and pars alpha shifted from the lateral paragigantocellular nucleus towards the RVM in rostral direction. Connections from the raphe magnus were altogether restricted to the RVM and the medial aspects of the lateral paragigantocellular nucleus. The diffuse and dense intramedullary connections of the raphe obscurus suggest that it might have an important role in coordinating the activity of rostral ventral medullary cells. The raphe pallidus and the ventral gigantocellular nuclei, areas that were innervated from widespread regions of the rostral ventral medulla but gave only limited projections there, are more likely to be involved in the direct descending control of spinal activities.

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