Journal of the autonomic nervous system
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J. Auton. Nerv. Syst. · May 1995
Internal connections in the rostral ventromedial medulla of the rat.
Physiological and pharmacological data suggest that the rostral ventromedial medulla (RVM) is an important site where integration between somatic and visceral functions might occur. The aim of the present study was to describe the interconnections between various nuclei of the rostral ventromedial medulla and thus reveal the possible anatomical basis for such functional interactions. The topography of anterogradely labelled internal projections was examined following iontophoretic microinjections of Phaseolus vulgaris leucoagglutinin (PHA-L). ⋯ Connections from the raphe magnus were altogether restricted to the RVM and the medial aspects of the lateral paragigantocellular nucleus. The diffuse and dense intramedullary connections of the raphe obscurus suggest that it might have an important role in coordinating the activity of rostral ventral medullary cells. The raphe pallidus and the ventral gigantocellular nuclei, areas that were innervated from widespread regions of the rostral ventral medulla but gave only limited projections there, are more likely to be involved in the direct descending control of spinal activities.