• H Nastou, G Sarros, A Nastos, V Sarrou, and J Anastassopoulou.
• Anaesthesiology Department 26, Ophthalmiatrio of Athens, Greece.
• Magnes Res. 1995 Sep 1; 8 (3): 271-6.

AbstractThe pharmacological effects of magnesium sulphate heptahydrate (MgSO4.7H2O) on hypertensive patients during the perioperative period were used, to control critical rises of blood pressure. This double-blind study included 40 hypertensive elderly patients, who underwent eye surgery under local anaesthesia; they were divided into two groups (A and B) of 20 patients each. An intravenous dose of 4g MgSO4.7H2O was given to group. A, while group B, which was used as a control group, was given to a placebo. All patients were premedicated with 10 mg oral diazepam 1.5 h before the operation. Systolic and diastolic blood pressure, heart rate and ECG were monitored for 1 h. None of the patients who received MgSO4.7H2O showed any ECG disturbances. Systolic and diastolic blood pressure, as well as heart rate, fluctuated outside the critical range, whereas in the control group an increase of blood pressure was noted which was treated with other anti hypertensive drugs. The results indicated that parenteral administration of MgSO4.7H2O in hypertensive patients before surgery stabilized blood pressure fluctuations outside the critical range, without causing the pressure to fall to a level that might risk undesirable side effects during eye surgery under local anaesthesia.

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