Magnesium research : official organ of the International Society for the Development of Research on Magnesium
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Randomized Controlled Trial Clinical Trial
Prophylactic effects of intravenous magnesium on hypertensive emergencies after cataract surgery. A new contribution to the pharmacological use of magnesium in anaesthesiology.
The pharmacological effects of magnesium sulphate heptahydrate (MgSO4.7H2O) on hypertensive patients during the perioperative period were used, to control critical rises of blood pressure. This double-blind study included 40 hypertensive elderly patients, who underwent eye surgery under local anaesthesia; they were divided into two groups (A and B) of 20 patients each. An intravenous dose of 4g MgSO4.7H2O was given to group. ⋯ None of the patients who received MgSO4.7H2O showed any ECG disturbances. Systolic and diastolic blood pressure, as well as heart rate, fluctuated outside the critical range, whereas in the control group an increase of blood pressure was noted which was treated with other anti hypertensive drugs. The results indicated that parenteral administration of MgSO4.7H2O in hypertensive patients before surgery stabilized blood pressure fluctuations outside the critical range, without causing the pressure to fall to a level that might risk undesirable side effects during eye surgery under local anaesthesia.