• Zang-Hee Cho, Meng Law, Je-Geun Chi, Sang-Hen Choi, Sung-Yeon Park, Alexandra Kammen, Chan-Woong Park, Se-Hong Oh, and Young-Bo Kim.
• Neuroscience Research Institute, Gachon University, Incheon, Korea.
• World Neurosurg. 2015 Jan 1;83(1):54-61.e32.

BackgroundImages obtained through ultra-high-field 7.0-tesla magnetic resonance imaging with track-density imaging provide clear, high-resolution tractograms that have been hitherto unavailable, especially in deep brain areas such as the limbic and thalamic regions. This study is a largely pictorial description of the deep fiber tracts in the brain using track-density images obtained with 7.0-T diffusion-weighted imaging.MethodsTo identify the fiber tracts, we selected 3 sets of tractograms and performed interaxis correlation between them. These tractograms offered an opportunity to extract new information in areas that have previously been difficult to examine using either in vivo or in vitro human brain tractography.ResultsWith this new technique, we identified 4 fiber tracts that have not previously been directly visualized in vivo: septum pellucidum tract, anterior thalamic radiation, superolateral medial forebrain bundle, and inferomedial forebrain bundle.ConclusionsWe present the high-resolution images as a tool for researchers and clinicians working with neurodegenerative and psychiatric diseases, such as Parkinson disease, Alzheimer disease, and depression, in which the accurate positioning of deep brain stimulation is essential for precise targeting of nuclei and fiber tracts.Copyright © 2015 Elsevier Inc. All rights reserved.

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