• Filippo Migliorini, Nicola Maffulli, Alice Baroncini, Matthias Knobe, Markus Tingart, and Jörg Eschweiler.
• Department of Orthopaedics, University Clinic Aachen, RWTH Aachen University Clinic, Pauwellstr. 31, 52074 Aachen, Germany.
• Br. Med. Bull. 2021 Jun 10; 138 (1): 144-154.

IntroductionChondral defects of the talus are common and their treatment is challenging.Source Of DataRecent published literatures.Areas Of AgreementMembrane-induced Autologous Chondrocyte Implantation (mACI) and Autologous Matrix-Induced Chondrogenesis (AMIC) have been proposed as management for chondral defects of the talus.Areas Of ControversyIt is debated whether AMIC provides greater outcomes compared to mACI for chondral regeneration. Several clinical studies showed controversial results, and the best treatment has not yet been clarified.Growing PointsTo investigate whether AMIC provide superior outcomes than mACI at midterm follow-up.Areas Timely For Developing ResearchAMIC exhibits similar clinical results to mACI. However, AMIC involves one single surgical procedure, no articular cartilage harvest and hence no morbidity from it, no need for chondrocyte expansion in a separate laboratory setting. For these reasons, AMIC may be preferred to mACI.© The Author(s) 2021. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

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