• Turk J Med Sci · Aug 2021

    Effectiveness of mepolizumab therapy on symptoms, asthma exacerbations, steroid dependence and small airways in patients with severe eosinophilic asthma.

    • İnsu Yılmaz, Sakine Nazik Bahçecioğlu, Murat Türk, Nuri Tutar, Paçacı ÇetinGüldenG0000-0002-2368-3401Department of Chest Diseases, Division of Immunology and Allergy, Faculty of Medicine, Erciyes University, Kayseri, Turkey, and Bahar Arslan.
    • Department of Chest Diseases, Division of Immunology and Allergy, Faculty of Medicine, Erciyes University, Kayseri, Turkey
    • Turk J Med Sci. 2021 Aug 30; 51 (4): 1953-1959.

    Background/AimThe efficacy of mepolizumab has been largely demonstrated in clinical trials in patients with severe eosinophilic asthma (SEA). However, reports on experience with mepolizumab in a real-life cohort are limited. Moreover, data about the effectiveness of mepolizumab on small airways is scarce. This study evaluated the effectiveness of mepolizumab therapy on symptoms, asthma exacerbations, blood eosinophils, steroid dependence, and small airways in a real-life cohort of patients with SEA.Materials And MethodsWe retrospectively analyzed patients with SEA who were receiving fixed-dose mepolizumab. The effects of mepolizumab on clinical, laboratory, functional parameters were evaluated at 12th, 24th, and 52nd weeks. Small airways were assessed with the FEF 25-75.ResultsA total of 41 patients were enrolled in the study. Mepolizumab significantly reduced asthma exacerbation rates, reduced mOCS dose, and improved asthma control test (ACT) scores at 12th, 24th, and 52nd weeks. However, we found no significant changes in FEV1 and FEF25-75 values at baseline, 12th, 24th, and 52nd weeks (78.9 ± 23.3%, 82.9 ± 23.4%, 81.9 ± 23.9%, and 78.9 ± 23.5% for FEV1; 45.1 ± 23.1%, 48.8 ± 23.5%, 48.7 ± 23.1%, and 41.0 ± 20.1% for FEF25-75, respectively)ConclusionIn this study, mepolizumab significantly improved all outcomes (symptom scores, asthma exacerbations, OCS sparing, and blood eosinophils) except functional parameters. Still, despite the dose reduction in mOCS dosage, no significant deterioration was observed in FEV1 and FEF25-75 values.This work is licensed under a Creative Commons Attribution 4.0 International License.

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