• Gülsüm Akgün Çağlıyan, Sibel Hacıoğlu, Başak Ünver Koluman, Kadir İlkkılıç, Rukiye Nar, Mehmet Nuri Başer, Aslı Bozdemir, Hande Şenol, Nilay Şen Türk, Veysel Erol, Onurcan Yılıdırım, Ömer Çağlıyan, and Nil Güler.
• Department of Hematology, Faculty of Medicine, Pamukkale University, Denizli, Turkey
• Turk J Med Sci. 2021 Aug 30; 51 (4): 2112-2119.

Background/AimThe aim of the study was to evaluate the effect of Controlling Nutritional Status (CONUT) score on the prognosis in patients with diffuse large B-cell lymphoma (DLBCL).Materials And MethodsThe present study was a retrospective study. The CONUT score was calculated based on serum albumin, total cholesterol and lymphocyte levels. This study included a total of 266 patients, 131 (49.2%) were female and 135 (50.8%) were male. The median follow-up period was 51 months (range: 1–190).ResultsThe median age was 64 years. The cut off CONUT was 1.5. There was a significant difference between patients with high (≥ 2) or low (< 2) CONUT scores in terms of overall survival (OS) and progression-free survival (PFS). The 5-year OS and PFS in patients with high CONUT score was 52.1% and 49.7%. The 5-year OS and PFS in patients with low CONUT score was 79.8% and 75.6% (p < 0.001). In the multivariate analysis for OS, age ≥ 65 years (HR = 1.80, p = 0.028), Eastern Cooperative Oncology Group (ECOG) > 1 (HR = 2.04, p = 0.006), stage IIIA–IVB disease (HR = 2.75, p = 0.001) and the CONUT score (HR = 1.15, p = 0.003) were found statistically significant. In the multivariate analysis for PFS, age ≥ 65 years (HR = 2.02, p = 0.007), stage IIIA–IVB disease (HR = 2.42, p = 0.002) and the CONUT score (HR = 1.19, p = 0.001) were found to be significant parameters.ConclusionHigh CONUT score reduces OS and PFS in DLBCL. CONUT score is an independent, strong prognostic index in patients with DLBCL.This work is licensed under a Creative Commons Attribution 4.0 International License.

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