• Betânia Souza Monteiro, Ricardo Junqueira Del Carlo, Napoleão Martins Argôlo-Neto, Nance Beyer Nardi, Pablo Herthel Carvalho, Laila de Paula Bonfá, Pedro César Chagastelles, Higo Nasser Moreira, Marlene Is... more abel Vargas Viloria, and Bianka Souza dos Santos. less
• Department of Veterinary, Vila Velha University, Espirito Santo, Brazil. betania.monteiro@uvv.br
• Acta Cir Bras. 2012 Mar 1; 27 (3): 201-9.

PurposeTo evaluate the effects of mesenchymal stem cells (MSC) from eight mice C57BL/6 gfp(+) bone marrows expanded in cultures associated with platelets rich plasma (PRP) deriving from another eight mice, in the repair of critical defects in calvarial bone produced in twenty-four adult isogenic mice C57BL/6.MethodsThe animals were submitted to a cranial defect of 6.0mm in diameter and divided into two equal experimental groups. Control group did not receive treatment and the treated group received a MSC pellet containing 1.0 x 10(7) cells/mL associated with 50.0 µL of plasma gel containing 1.0 x 10(9) autologous platelets within the defect.ResultsIn the treated group was observed process of angiogenesis and bone repair better than control group.ConclusionMesenchymal stem cells derived from bone marrow of C57BL/6 gfp(+) mice associated with PRP gel applied in bone critical defects produced in calvarial contributes positively to the process of bone repair.

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