• Rev Esp Geriatr Gerontol · May 2021

    [Anemia and frailty in older adults from Spain. The FRADEA Study].

    • José Luis Esquinas-Requena, Inmaculada García-Nogueras, Pablo Hernández-Zegarra, Pilar Atienzar-Núñez, Pedro Manuel Sánchez-Jurado, and Pedro Abizanda.
    • Servicio de Geriatría, Hospital General Universitario de Ciudad Real, Ciudad Real, España. Electronic address: joseluis.esquinas@hotmail.com.
    • Rev Esp Geriatr Gerontol. 2021 May 1; 56 (3): 129-135.

    IntroductionThe objective was to examine the prevalence of anemia according to the state of frailty and to analyze the relationship between anemia, hemoglobin concentration and frailty in a cohort of Spanish older adults.Material And MethodsCross-sectional substudy of the FRADEA (Frailty and Dependency in Albacete) cohort, a population-based concurrent cohort study conducted in people older than 69 years of Albacete (Spain). Of the 993 participants included in the first wave, 790 were selected with valid data on anemia and frailty. Anemia was defined according to the criteria of the World Health Organization (hemoglobin less than 13 g/dL in men and 12 g/dL in women). Frailty was assessed using the Fried's phenotype. The association between anemia, hemoglobin concentration and frailty was determined by binary logistic regression adjusted for age, sex, educational level, institutionalization, comorbidity, cognitive status, body mass index, polypharmacy, creatinine, glucose and total white blood cell count.ResultsThe mean age was 79 years. The prevalence of anemia was 19.6%. The prevalence of anemia was significantly higher in frail subjects (29.6%) compared to prefrail (16.6%) and robust ones (6%), p<0.001. The average hemoglobin concentrations were significantly lower in frail (12.7 g/dL), compared to the prefrail (13.5 g/dL) and robust participants (14.4 g/dL), p < 0.001. In the fully adjusted regression model, anemia was associated with frailty (OR 1.95; 95% CI: 1.02-3.73, p<0.05), and similarly, the average hemoglobin concentrations showed a significant association with frailty (OR 0.79; 95% CI: 0.66-0.96, p < 0.05).ConclusionAnemia in older adults, defined according to WHO criteria, is independently associated with frailty.Copyright © 2021 SEGG. Publicado por Elsevier España, S.L.U. All rights reserved.

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