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- Hideo Shiohira, Masashi Nakamatsu, Yuya Kise, Futoshi Higa, Masao Tateyama, Nobuo Hokama, Yukio Kuniyoshi, Shinichiro Ueda, Katsunori Nakamura, and Jiro Fujita.
- Department of Hospital Pharmacy, Faculty of Medicine, University of the Ryukyus.
- Yakugaku Zasshi. 2016 Jan 1; 136 (9): 1313-7.
AbstractTeicoplanin, a glycopeptide antibiotic for methicillin-resistant Staphylococcus aureus, is recommended for therapeutic drug monitoring during treatment. Maintaining a high trough range of teicoplanin is also recommended for severe infectious disease. However, the optimal dose and interval of treatment for severe renal impairment is unknown. We report a 79-year-old man who received long-term teicoplanin treatment for methicillin-resistant Staphylococcus aureus bacteremia due to postoperative sternal osteomyelitis with renal impairment. Plasma teicoplanin trough levels were maintained at a high range (20-30 μg/mL). Although the patient required long-term teicoplanin treatment, a further decline in renal function was not observed, and blood culture remained negative after the start of treatment. Teicoplanin treatment that is maintained at a high trough level by therapeutic drug monitoring might be beneficial for severe methicillin-resistant Staphylococcus aureus infection accompanied by renal impairment.
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