• Current drug targets · Sep 2009

    Review

    Beta-Blockers in the perioperative period: are there indications other than prevention of cardiac ischemia?

    • Yuji Kadoi and Shigeru Saito.
    • Department of Anesthesiology, Gunma University, Graduate School of Medicine, Showa-machi, Maebashi, Gunma 371-8511, Japan. kadoi@med.gunma-u.ac.jp
    • Curr Drug Targets. 2009 Sep 1; 10 (9): 842-9.

    AbstractBeta-blocker therapy is accepted to reduce perioperative cardiovascular complications. Moreover, beta-blockers have potentially beneficial effects other than prevention of cardiac events. In addition to reducing anesthetic and analgesic requirements during the perioperative period, beta-blockers have neuroprotective effects, possible effectiveness in the management of intraoperative awareness-induced post-traumatic stress disorder, and antinociceptive effects. Beta-blockers are also useful in stabilizing hemodynamics during electroconvulsive therapy, intubation and emergency periods. Physicians need to bear in mind the benefits of beta-blockers for purposes other than preventing cardiac events when applied in the perioperative period, and should be familiar with the pharmacodynamics and effective dosages of these agents.

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