• Lung Cancer · Dec 2016

    Case Reports

    Histological transformation of ALK rearranged adenocarcinoma into small cell lung cancer: A new mechanism of resistance to ALK inhibitors.

    • Delphine Levacq, Nicky D'Haene, Roland de Wind, Myriam Remmelink, and Thierry Berghmans.
    • Department of Medical Oncology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.
    • Lung Cancer. 2016 Dec 1; 102: 38-41.

    AbstractVarious mechanisms of resistance to ALK inhibitors in ALK rearranged adenocarcinomas are reported including secondary gatekeeper mutations, bypass signaling or ALK amplifications as the commonest ones. We report a new mechanism of resistance with transformation of adenocarcinoma into small cell lung cancer. A 53-year-old non-smoker woman, experienced cancer progression after two lines of ALK inhibitors. A new biopsy showed a small cell lung cancer. FISH revealed persistent ALK rearrangement with an atypical pattern and complete loss of the 5' region of the ALK gene.Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

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