• Gökhan Akkurt, Bahar Kartal, Mustafa Alimoğulları, Sevil Çaylı, and Ebru Alimoğulları.
• Department of Surgical Oncology, Ankara City Hospital, Ankara, Turkey
• Turk J Med Sci. 2021 Aug 30; 51 (4): 2213-2221.

Background/AimWe aimed to investigate whether there was a significant difference in TSH, T3, T4 values and histopathologically evaluated thyroid tissues between rats that received ısole hydrolyzed whey protein (IHWP) at different doses regularly and rats fed with only standard feed.Material & MethodsTotal 24 rats were randomly divided into three groups with 8 rats in each group. First group were fed with standard feed for 12 weeks. Second group were given standard feed + daily 0.3 g/kg IHWP and rats in the third group standard feed + 0.5 g/kg IHWP for 12 weeks. Blood samples were collected from all rats before and after IHWP administration. All rats were then sacrificed, and thyroid tissues were histopathologically examined.ResultsInterfollicular connective tissue areas and TSH (0.35–4.90 μIU/L) were higher in the control group compared to 3 cc IHWP and 5 cc IHWP groups, while thyroid hormone T4 (0.7–1.48 ng/dL), and thyroid hormone synthesis parameters including intrafollicular colloid amount, follicular diameter, and epithelial height were significantly higher in 3 cc and 5 cc IHWP groups compared to the control.ConclusionWe think that regular daily use of IHWP may increase the synthesis of thyroid hormone due to its high amino acid content.This work is licensed under a Creative Commons Attribution 4.0 International License.

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