• Pediatric blood & cancer · Jan 2021

    Review

    A review of the clinical applications of ketamine in pediatric oncology.

    • Satya Prakash, Aditya Kumar Gupta, Jagdish Prasad Meena, and Rachna Seth.
    • Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
    • Pediatr Blood Cancer. 2021 Jan 1; 68 (1): e28785.

    AbstractKetamine is a dissociative anesthetic agent with excellent analgesic properties and a favorable safety profile. The feasibility and efficacy of various routes of administration have been established, including intravenous (IV), intramuscular (IM), oral, intranasal, rectal, and transdermal routes. The advent of newer anesthetic agents has led to a decline in the use of ketamine as an anesthetic, but its utility in short-term sedation and analgesia has expanded. Its value for chronic pain management in children with cancer is being increasingly recognized but requires more evidence. The use of topical ketamine is largely in investigational stages. Medical use of ketamine is, to a great extent, free from significant long-term neurological side effects. The objective of this review is to provide a brief account of the pharmacology of ketamine and primarily focus on the clinical applications of ketamine in pediatric oncology.© 2020 Wiley Periodicals LLC.

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