• Biology of the neonate · Jan 1994

    Development of morphine glucuronidation in premature neonates.

    • R Hartley, M Green, M W Quinn, J A Rushforth, and M I Levene.
    • Department of Clinical Medicine, University of Leeds, UK.
    • Biol. Neonate. 1994 Jan 1; 66 (1): 1-9.

    AbstractIn premature neonates (25-34 weeks gestation) who were given morphine intravenously during the first 24 h of life, only morphine, and morphine-3-glucuronide (M3G) were detected in plasma obtained after a 2-hour loading infusion, but morphine-6-glucuronide (M6G) could also be quantified following 24 h of continuous infusion. M3G/morphine and M6G/morphine plasma concentration ratios increased significantly with increasing birth weight. However, the M6G/M3G plasma concentration ratio decreased with increasing birth weight (and gestational age), thus providing the first indication in vivo of the differential development of uridinediphosphate glucuronosyltransferases in humans.

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