• Sarkis Kiramijyan, Edward Koifman, Marco A Magalhaes, Itsik Ben-Dor, Romain Didier, Zachary D Jerusalem, Sandeep Kumar, Arpi Tavil-Shatelyan, Toby Rogers, Arie Steinvil, Jiaxiang Gai, Rebecca Torguson, Lowell F Satler, Augusto D Pichard, and Ron Waksman.
• Section of Interventional Cardiology, MedStar Washington Hospital Center, Georgetown University Hospital, Washington, D.C., USA.
• Cardiovasc Revasc Med. 2018 Apr 1; 19 (3 Pt A): 257-262.

ObjectiveEvaluation of invasive hemodynamic parameters as prognostic markers of mortality in patients undergoing TAVR.BackgroundThe value of invasive intraprocedural hemodynamic evaluation of patients undergoing transcatheter aortic valve replacement is unclear.MethodsConsecutive patients who underwent transfemoral TAVR and had complete prospectively collected intraprocedural invasive hemodynamic parameters were retrospectively analyzed. Patients with alternative access, planned general anesthesia, or baseline ≥moderate Tricuspid Regurgitation were excluded. Pre- and post-valve implant parameters included heart rate, systolic and diastolic blood pressures, cardiac output and index, pulmonary arterial systolic and diastolic pressures, transaortic pressure gradient and right atrial pressure. The primary end points were the association of the intraprocedural hemodynamic changes with all-cause mortality at 30days and 1year. Extensive Receiver Operating Characteristic analyses yielded dichotomized threshold of hemodynamic values in association with the binary outcome of mortality.ResultsA total of 312 patients (52% male, mean age 83years) were evaluated. A significant association with 30-day and 1-year mortality was found between intraprocedural post-valve implant cardiac index <1.9 vs. ≥1.9L/min/m2 (Log-ranked p=0.0286 and p=0.0432, respectively). Four subgroups with pre- and post-valve implant CI changes (L/min/m2) were compared: [1] pre<1.9, stable_post<1.9; [2] pre<1.9, improved_post≥1.9; [3] pre≥1.9, stable_post≥1.9; and [4] pre≥1.9, worsened_post<1.9. Group 1 (lower CI with no post-valve improvement) had the worst survival, and Group 3 (higher CI and stable post-valve) had the best survival at 1-year follow-up (Log-ranked p=0.0089).ConclusionsIn patients with severe aortic stenosis undergoing TAVR, invasive monitoring can assess for hemodynamic prognostic markers of survival.Copyright © 2017 Elsevier Inc. All rights reserved.

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