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Bull. Exp. Biol. Med. · Nov 2014
Experimental study of the efficiency of oxidized dextran for prevention of influenza A/H5N1.
- V A Shkurupy, O V Potapova, T V Sharkova, A V Troitskii, E P Gulyaeva, T N Bystrova, and A M Shestopalov.
- Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia.
- Bull. Exp. Biol. Med. 2014 Nov 1; 158 (1): 112-4.
AbstractOxidized dextran is suggested for prevention of infection induced by influenza A/H5N1 viruses, methods of its use and doses are determined. Two intravenous injections of dextran 3 and 1 days before experimental infection of outbred mice by influenza A/H5N1 A/goose/Krasnoozerskoye/627/05 virus resulted in a high preventive dose-dependent effect: the mean lifespan was 25% prolonged, the mortality decreased 3-fold.
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