• Rev Lat Am Enfermagem · Oct 2018

    Hemolysis risk after packed red blood cells transfusion with infusion pumps.

    • Ana Maria Miranda Martins Wilson, Peterlini Maria Angélica Sorgini MAS Universidade Federal de São Paulo, Escola Paulista de Enfermagem, São Paulo, SP, Brazil., and Pedreira Mavilde da Luz Gonçalves MDLG Universidade Federal de São Paulo, Escola Paulista de Enfermagem, São Paulo, SP, Brazil..
    • Universidade de São Paulo, Escola de Enfermagem, São Paulo, SP, Brazil.
    • Rev Lat Am Enfermagem. 2018 Oct 11; 26: e3053.

    ObjectiveTo evaluate the hemolysis biomarkers of packed red blood cells transfused by two different linear peristaltic infusion pumps at two infusion rates.MethodAn experimental and randomized study was designed simulating the clinical practice of transfusion. Two linear peristaltic infusion pumps from different manufactures were studied in triplicate at 100 mL/h and 300mL/h infusion rates. The chosen hemolysis biomarkers were total hemoglobin, free hemoglobin, hematocrit, potassium and degree of hemolysis. They were analyzed before and after each infusion.ResultsPotassium showed statistically significant variations in all scenarios of the experiment (P<0.010). In a separated analysis, potassium increased mainly at 300mL/h rate (P=0.021) and free hemoglobin had significant variation when comparing infusion pumps from different manufacturers (P=0.026). Although hematocrit, total hemoglobin and degree of hemolysis had increased after infusion, no statistically significance variations were identified.ConclusionsHemolysis risk induced by a linear peristaltic infusion pump was identified by an increase in free hemoglobin and potassium markers. As the potassium biomarker is often increased in aged packed red blood cells, we do not recommend using them in this scenario. Additional studies should be performed about other markers and using larger samples in order to reinforce the transfusion practice in nursing.

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