• Clin. Vaccine Immunol. · Jul 2012

    Comparative Study

    Analysis of variola and vaccinia virus neutralization assays for smallpox vaccines.

    • Christine M Hughes, Frances K Newman, Whitni B Davidson, Victoria A Olson, Scott K Smith, Robert C Holman, Lihan Yan, Sharon E Frey, Robert B Belshe, Kevin L Karem, and Inger K Damon.
    • National Center for Emerging and Zoonotic Infectious Diseases, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. Christine.Hughes@cdc.hhs.gov
    • Clin. Vaccine Immunol. 2012 Jul 1; 19 (7): 1116-8.

    AbstractPossible smallpox reemergence drives research for third-generation vaccines that effectively neutralize variola virus. A comparison of neutralization assays using different substrates, variola and vaccinia (Dryvax and modified vaccinia Ankara [MVA]), showed significantly different 90% neutralization titers; Dryvax underestimated while MVA overestimated variola neutralization. Third-generation vaccines may rely upon neutralization as a correlate of protection.

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