-
Clin. Vaccine Immunol. · Jul 2012
Comparative StudyAnalysis of variola and vaccinia virus neutralization assays for smallpox vaccines.
- Christine M Hughes, Frances K Newman, Whitni B Davidson, Victoria A Olson, Scott K Smith, Robert C Holman, Lihan Yan, Sharon E Frey, Robert B Belshe, Kevin L Karem, and Inger K Damon.
- National Center for Emerging and Zoonotic Infectious Diseases, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. Christine.Hughes@cdc.hhs.gov
- Clin. Vaccine Immunol. 2012 Jul 1; 19 (7): 1116-8.
AbstractPossible smallpox reemergence drives research for third-generation vaccines that effectively neutralize variola virus. A comparison of neutralization assays using different substrates, variola and vaccinia (Dryvax and modified vaccinia Ankara [MVA]), showed significantly different 90% neutralization titers; Dryvax underestimated while MVA overestimated variola neutralization. Third-generation vaccines may rely upon neutralization as a correlate of protection.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*,_underline_or**bold**. - Superscript can be denoted by
<sup>text</sup>and subscript<sub>text</sub>. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3., hyphens-or asterisks*. - Links can be included with:
[my link to pubmed](http://pubmed.com) - Images can be included with:
 - For footnotes use
[^1](This is a footnote.)inline. - Or use an inline reference
[^1]to refer to a longer footnote elseweher in the document[^1]: This is a long footnote..