• Agnieszka Piątek-Guziewicz, Paweł Paśko, Kacper Wcisło, Agnieszka Dąbek-Drobny, Magdalena Przybylska-Feluś, Olga Kaczmarczyk, Paweł Zagrodzki, Tomasz Mach, and Małgorzata Zwolińska-Wcisło.
• Department of Gastroenterology and Hepatology, Jagiellonian University Medical College, Kraków, Poland
• Pol. Arch. Med. Wewn. 2021 Aug 30; 131 (7-8): 701-708.

IntroductionPatients with inflammatory bowel disease (IBD) can experience micronutrient deficiency regardless of disease activity and extent.ObjectivesWe aimed to evaluate serum concentrations of selected trace elements in adult patients with IBD in clinical remission with involvement limited to the colon who received immunosuppressive treatment.Patients And MethodsWe enrolled 32 patients with IBD (mean [SD] age, 41 [15.2] years) and 30 healthy controls (mean [SD] age, 39.1 [11.8] years). Serum selenium, iron, copper, and zinc levels as well as complete blood count were measured in both groups.ResultsPatients with IBD had lower zinc concentrations than controls (mean [SD], 0.76 [0.13] mg/l vs 0.83 [0.13] mg/l; P = 0.047). No differences were observed for selenium (mean [SD], 0.90 [0.24] μmol/l vs 0.93 [0.19] μmol/l) and copper levels (mean [SD], 1.03 [0.27] mg/l vs 0.97 [0.22] mg/l). Compared with controls, patients with IBD had lower red blood cell count (mean [SD], 4.4 [0.6] 106/μl vs 4.7 [0.4] 106/μl; P = 0.03), hemoglobin (mean [SD], 12.7 [2.2] g/dl vs 14.3 [0.8] g/dl; P = 0.001), and iron levels (mean [SD], 14.2 [9.4] μmol/l vs 23.4 [2.7] μmol/l; P = 0.0001). Patients with IBD showed a positive correlation between selenium and iron (R = 0.499; P = 0.004) as well as selenium and hemoglobin levels (R = 0.579; P = 0.001).ConclusionsPatients with IBD, despite maintaining clinical remission, should undergo systematic laboratory test for anemia or micronutrient deficiencies.

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