• BJOG · Jan 2017

    Review

    A review of the available clinical therapies for vulvodynia management and new data implicating proinflammatory mediators in pain elicitation.

    • M L Falsetta, D C Foster, A D Bonham, and R P Phipps.
    • Department of Environmental Medicine, University of Rochester, Rochester, NY, USA.
    • BJOG. 2017 Jan 1; 124 (2): 210-218.

    AbstractLocalised provoked vulvodynia (LPV) is a common, chronic, and disabling condition: patients experience profound pain and a diminished quality of life. The aetiologic origins of vulvodynia are poorly understood, yet recent evidence suggests a link to site-specific inflammatory responses. Fibroblasts isolated from the vestibule of LPV patients are sensitive to proinflammatory stimuli and copiously produce pain-associated proinflammatory mediators (IL-6 and PGE2 ). Although LPV is a multifactorial disorder, understanding vulvar inflammation and targeting the inflammatory response should lead to treatment advances, especially for patients exhibiting signs of inflammation. NFκB (already targeted clinically) or other inflammatory components may be suitable therapeutic targets.© 2016 Royal College of Obstetricians and Gynaecologists.

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