• Cleve Clin J Med · Oct 2015

    Randomized Controlled Trial

    A new class of drugs for systolic heart failure: The PARADIGM-HF study.

    • Marwa A Sabe, Miriam S Jacob, and David O Taylor.
    • Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA.
    • Cleve Clin J Med. 2015 Oct 1; 82 (10): 693-701.

    AbstractThe PARADIGM-HF trial (Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure) found a combination drug containing sacubitril (a neprilysin inhibitor) and valsartan (an angiotensin II receptor blocker) superior to enalapril (an angiotensin-converting enzyme inhibitor) in patients with systolic heart failure. Recently approved by the US Food and Drug Administration, sacubitril-valsartan is the first new drug in over a decade to decrease death rates in patients with systolic heart failure. Copyright © 2015 Cleveland Clinic.

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