• Minerva cardioangiologica · Jun 1994

    Randomized Controlled Trial Comparative Study Clinical Trial

    [A comparison between propafenone and amiodarone in the conversion to sinus rhythm of atrial fibrillation of recent onset].

    • A Treglia, C Alfano, and E Rossini.
    • Sezione Autonoma di Cardiologia, Presidio Ospedaliero di Formia, Regione Lazio, USL LT/6, Latina.
    • Minerva Cardioangiol. 1994 Jun 1; 42 (6): 293-7.

    AbstractThe effectiveness of propafenone versus amiodarone for conversion to sinus rhythm of paroxysmal atrial fibrillation was compared. Fifty-four consecutive adult patients affected by recent onset atrial fibrillation (< 7 days) were randomized to treatment with intravenous propafenone (27 patients) and amiodarone (27 patient). Sinus rhythm was restored respectively in 74.1% and 70.4% (p = ns); within 5 hours was obtained reconversion in 65% of propafenone and in 15.8% of amiodarone group (p < 0.05); the mean conversion time was 3.5 and 16.6 hours (p < 0.01). In conclusion propafenone seems to be as effective and safe as amiodarone, but is significantly fast in converting recent onset atrial fibrillation to sinus rhythm.

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