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Randomized Controlled Trial Clinical Trial
Enteric-coated pelletized aspirin. Gastrointestinal blood loss and bioavailability.
- I Portek, G Graham, and A Fleming.
- Med. J. Aust. 1981 Jul 11; 2 (1): 39-40.
AbstractEleven patients suffering from arthritis received, in a randomized cross-over study, anti-inflammatory doses of two aspirin formulations: Enpryn, capsules containing enteric-coated pellets; Rhusal, an enteric-coated tablet. No significant difference was found between the two formulations with respect to gastrointestinal microbleeding, plasma salicylate levels and urinary recovery of salicylate. Bioavailability studies carried out on 10 healthy male volunteers demonstrated that absorption from the enteric-coated pellet capsules was sustained and complete.
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