• Methods Mol. Biol. · Jan 2018

    An In Vivo Compression Model of Spinal Cord Injury.

    • Irene Paterniti, Emanuela Esposito, and Salvatore Cuzzocrea.
    • Department of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, Messina, Italy.
    • Methods Mol. Biol. 2018 Jan 1; 1727: 379-384.

    AbstractAnimal spinal cord injury (SCI) models have proven highly useful for investigating the mechanisms involved in the injury process and evaluating the effectiveness of experimental therapeutic interventions. Over the last years, substantial improvements have been made in producing consistent and reproducible animal SCI models. Different SCI models have been developed to address the mechanism of injury, being divided into contusion, compression, distraction, dislocation, transection, or chemical models. The method described here is a mouse compression model of SCI that, in many respects, faithfully reproduces SCI in man.

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