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- Krystian Kaczmarek, Artur Lemiński, Adam Gołąb, and Marcin Słojewski.
- Department of Urology and Urological Oncology, Pomeranian Medical University, Szczecin, Poland.
- Arch Med Sci. 2021 Jan 1; 17 (3): 603-612.
IntroductionWorse survival in upper tract urothelial carcinoma (UTUC) in the presence of a tumour in the ureter vs. pelvicalyceal tumours is reported in some studies; however, the definition of ureteral involvement (UI) varies across studies. We systematically evaluated evidence regarding the prognostic role of UI in overall and cancer-specific survival of patients with UTUC.Material And MethodsA systematic search of PubMed, Scopus and Web of Knowledge was performed in March 2018.ResultsThe results were presented as a comparison between ureteral vs. pelvicalyceal tumours. A total of 14,895 patients were identified. Cumulative analyses indicated that UI worsens cancer-specific survival (CSS) and overall survival (OS), with a pooled HR of 1.52 (p < 0.001) and 1.39 (p = 0.004), respectively.ConclusionsOur meta-analysis identified UI in UTUC as an adverse prognostic factor.Copyright: © 2019 Termedia & Banach.
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