• Liucija Rita Cerniauskiene, Dalia Ieva Luksiene, Abdonas Tamosiūnas, Regina Reklaitiene, and Lilija Margeviciene.
• Institute of Cardiology, Kaunas University of Medicine, Lithuania. klbioch@kmu.lt
• Medicina (Kaunas). 2008 Jan 1; 44 (5): 392-9.

UnlabelledThe aim of this study was to evaluate the association of metabolic syndrome and oxidative stress with ischemic heart disease in middle-aged persons (men and women aged 45-64 years).Material And MethodsIn this study, we have used data of 533 persons (247 men and 286 women) aged 45-64 years from Kaunas population cohort investigated according to WHO MONICA study protocol during 2001-2002 in whom concentrations of malondialdehyde, a marker of lipid peroxidation, and antioxidant vitamin E in blood serum were determined. Metabolic syndrome was defined by the criteria of Adult Treatment Panel III. Oxidative stress was determined in the presence of increased level of malondialdehyde (> or =5 micromol/L) and decreased level of lipid-standardized vitamin E (<20 micromol/L). The levels of malondialdehyde and vitamin E were measured by fluorimetric methods.ResultsIschemic heart disease was diagnosed in 19.8% of men and 21.3% of women. The frequency of ischemic heart disease among persons (men and women) with metabolic syndrome was significantly higher than among persons without metabolic syndrome (27.4% vs. 17.8%, respectively; odds ratio, 1.63; P=0.032). The frequency of ischemic heart disease among persons with oxidative stress was significantly higher than among persons without oxidative stress (29.1% vs. 17.6%, respectively; odds ratio, 1.88; P=0.029). The highest prevalence of ischemic heart disease (30.0%) was among persons with metabolic syndrome and oxidative stress, and the lowest prevalence of this disease (13.8%) was among persons without metabolic syndrome and without oxidative stress (odds ratio, 2.54; P=0.017). These data were adjusted by sex and age.ConclusionMetabolic syndrome and oxidative stress are significantly associated with ischemic heart disease among 45-64-year-old persons.

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